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Pathophysiologic Context In PAH + HFpEF overlap: * ETA receptors drive vasoconstriction, hypertrophy, and fibrosis * ETB receptors mediate endothelin clearance, nitric oxide release, and natriuresis * HFpEF patients rely on ETB signaling to maintain volume balance and endothelial function Blocking ETB in HFpEF increases the risk of fluid retention and rising leftsided filling pressures
2025 Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society
Extreme caution is advised in patients with epilepsy, advanced age, or chronic pulmonary disease because hypoxia and acidosis lower the seizure threshold and potentiate cardiotoxicity
Storage conditions during international shipping are uncontrolled
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doi: 10.4103/aja.aja_5_19 207 AgarwalARoychoudhurySSharmaRGuptaSMajzoubASabaneghE
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