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( 10.4103/0970-1591.78437) [DOI] [PMC free article] [PubMed] [Google Scholar] Agarwal A, Virk G, Ong C, Du Plessis SS.2014

[DOI] [PubMed] [Google Scholar] 96.Nicassio L., Fracasso F., Sirago G., Musicco C., Picca A., Marzetti E., Calvani R., Cantatore P., Gadaleta M.N., Pesce V

Gastrointestinal adverse events were reported in 62% of the group taking semaglutide, compared to 42% in the placebo group.[ref] Bigger picture of GLP-1 in the rise of obesity: Several recent studies shed light on how environmental factors may be causing a decrease in GLP-1 levels

Semaglutide is a GLP-1 receptor agonist that works by: Suppressing Appetite: The medication reduces hunger signals in the brain, helping individuals consume fewer calories

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use