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PLoS One (2013) 8(5):e63626.10.1371/journal.pone.0063626 129 Fukuda-TsuruSKakimotoTUtsumiHKiuchiSIshiiS

Novo Nordisk, the manufacturer of Ozempic, Rybelsus, and Wegovy, owns several patents on semaglutide

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In rodents, CYP induction decreases ITZ-associated hepatotoxicity while CYP inhibition increases toxicity, so either the parent compound or metabolites produced by an alternative pathway likely cause toxicity (32, 40)