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What You Should Discuss With Your Healthcare Provider Before donating plasma, inform your provider that you take semaglutide and ask whether your current dosing, nutrition status, and recent lab work support donation safety

A recent case reminded me of this: BMI 66, severe steatosis (S3), FibroScan 18 kPa F4 by stiffness criteria yet: Normal ultrasound Normal platelets Low FIB-4 No clinical signs of portal hypertension According to AASLD 2024 Rule of 5 and EASL 2025 guidelines, this patient should not be classified as cACLD the stiffness is likely overestimated due to technical and metabolic factors (high BMI, severe fat infiltration, and shear-wave attenuation)