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A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings

The similar effects resulting from the treatments with the supplements and with the lotion clearly indicate that the topical application successfully delivers the active ingredients to the hair follicle to a similar degree as the systemic application

This oxidant stress causes activation of a MAP kinase cascade in the cytosol ultimately leading to phosphorylation of c-jun N-terminal kinase (P-JNK), translocation of P-JNK to the mitochondria [34], and binding to the anchor protein Sab [35] for amplification of the mitochondrial oxidant stress and peroxynitrite formation in the mitochondrial matrix [33, 36]

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