semaglutide hold before surgery on Semaglutide: Perioperative Safety Guide When to Stop Semaglutide Before

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Over 39 months mean follow-up, the primary composite outcome of MACE (cardiovascular death, non-fatal MI, non-fatal stroke) dropped 20% in the semaglutide group

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This association extended to symptoms like anxiety and depression, suggesting pharmacologic mechanisms at play, such as reduced chronic inflammation and improved endothelial function