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Mounjaro, Zepbound, and Trulicitys labels include robust, FDA-approved warnings, and have always warned of potential gastrointestinal adverse reactions, sometimes severe. He added, As part of our routine safety review process for Mounjaro, Zepbound and Trulicity, we work closely with regulators regarding potential safety topics, and we will continue to review data to ensure that appropriate safety information is available to prescribers. Ana Santos Rutschman, a health law professor at Villanova University, said proving the drugs caused certain outcomes will be an issue as the legal battle unfolds, along with the extent and timing of warnings

Unlike semaglutide, which only targets GLP-1 receptors, tirzepatide is a dual agonist that targets GLP-1 and glucagon receptors

Thinner subcutaneous fat layer plus same needle length equals higher probability of reaching muscle