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For those who do not meet their glycaemic targets after initial metformin treatment, current American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) guidelines recommend intensifying treatment with sulfonylureas (SU), thiazolidinediones (TZD), dipeptidyl peptidase-4 inhibitors (DPP-4i), sodium-glucose co-transporter-2 inhibitors (SGLT-2is) or glucagon-like peptide 1 receptor agonists (GLP-1 RAs) [10]

The GIP receptor pathway may offer additional cognitive and emotional benefits that pure GLP-1 agonists do not provide