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SLC25A11 belongs to the solute carrier family 25 (SLC25), which encompasses 53 known carrier proteins that play critical roles in regulating cellular metabolism and physiological processes (reviewed in Kunji et al., 2020)

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Safety data indicate no major excess risk with combination therapy, although gastrointestinal effects and class-specific adverse events remain relevant

Cell-based assays use both heterologous expression in CHO-K1 and HEK293 cells and pituitary-derived cell lines retaining endogenous GHRH-R