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Tio first proposed the term melanocytoma in 1972, who described a pigment-containing tumor with the histological features of both meningioma and a lesion of melanocytic origin

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Some research has shown that even in the absence of functional beta-3 receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting the peptide may influence brown fat or thermogenic pathways through additional mechanisms