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The FDA applied a four-part statutory test under 21 CFR 216.23(c): physical and chemical characterization, historical compounding use, evidence of effectiveness, and safety
The benzyl alcohol does provide meaningful bacteriostatic protection at room temperature, and a freshly opened vial left at ambient temperature for a few hours is not immediately compromised
While not the main focus of the stack, these heart benefits add research value for studies of systemic health
Recommended to be used within 90 days of opening
Aqueous solvents such as sterile water or bacteriostatic water are preferred for in vivo rodent studies because they eliminate the confounding variable of DMSO's own biological activity, which includes membrane permeabilization and anti-inflammatory effects
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