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However, the direct effects of GLP-1RAs on fatty acid synthase expression and lipid metabolism remain unclear

doi:10.1016/j.cmet.2018.03.001 2

Consequently, GLP-1 RAs reduce blood glucose and glycated hemoglobin levels, facilitating weight loss and improving blood pressure and lipid profile in T2D patients

Fletcher and colleagues (J Pharmacol Exp Ther, 2021) profiled it across 25 endpoints against selective and non-selective comparators including pramlintide and salmon calcitonin, and cryo-EM structures of cagrilintide bound to CTR and the amylin receptors were reported by Cao and colleagues (Nat Commun, 2025)