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Moreover, HPLC-MS/MS techniques allow for the precise identification and quantification of ROS byproducts, providing detailed information on the types of oxidative damage occurring within the cell

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In both methods, the addition of methanol was important to induce a complete phase transfer of DDA-GSH-AuNCs into the organic layer, in agreement with previous reports in which common solvents were used to facilitate phase transfer of nanoclusters and nanoparticles across biphasic liquid systems 32,46,47,48,49

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The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies