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In two previous clinical trials, the combination use of vitamin B12 (500 g/day) and folic acid (5 mg/day) for about eight weeks led to a significant improvement in FBG levels and HOMA-IR 41,42

In contrast, the ansB gene encodes the Type II isoenzyme, which is inducible under nitrogen-limited conditions and has higher affinity for asparagine, making it the therapeutically relevant form used in clinical applications

Intramuscular vs Subcutaneous Parenteral administration of vitamin B-12 via injection has been standard protocol for decades, according to the Centers for Disease Control and Prevention

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