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Inadequate dosing intervals, missed injections, improper injection technique, concurrent medications that interfere with GLP-1 signaling, and unaddressed metabolic conditions (like thyroid dysfunction or polycystic ovary syndrome) can all suppress apparent medication response

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Liraglutide vs Semaglutide: 2.5x Weight Loss Gap STEP 8 head-to-head: 15.8% vs 6.4% weight loss

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Moreover, a serious limitation with these datasets is the lack of sufficient patient level data to assess key variables, including other PDAC risk factors (particularly diabetes and obesity) as well as dosing and duration of drug exposure

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