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Overexpression of HIF-2 decreases GPX4 levels and facilitates the activity of carnitine palmitoyltransferase 1A (CPT1A), which transports fatty acids into the mitochondrial matrix for -oxidation, thus aggravating cartilage degeneration (Zhou et al., 2021)

Importantly, antioxidant therapies may be most effective when combined with lifestyle interventions

Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model

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Another study however observed no abnormalities or changes in the fertility rate and other reproductive function parameters in rats treated with prebiotics (galacto-oligosaccharides) (179)