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How they compare: LillyDirect: $299 (2.5mg), $399 (5mg), $449 (7.5mg+) vials only, 45-day refill window for higher doses TrumpRx: ~$350/month flat rate may include pens, no refill timing requirement For the 2.5mg starting dose, LillyDirect is cheaper ($299 vs ~$350)

According to current NICE guidance (NG28), GLP-1 receptor agonists like Ozempic may be considered alongside metformin and SGLT2 inhibitors based on individual risk factors, preferences and comorbidities

To compare pre- and post-treatment data, we used the paired Students t-test when the assumption of normality was met

Tirzepatide at all doses outperformed semaglutide in HbA1c reduction, weight loss, and lipid improvements

By promoting weight loss, semaglutide may indirectly contribute to blood pressure reduction