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Peptide therapies may not be appropriate for every patient

10.1016/0028-3908(96)84626-0 34 GawrylukJ

In this review, examples will be discussed how experimental conditions (dose, solvent, etc.), the experimental system (species, strain, and substrain in vivo, cell type, and in vitro conditions), and also adaptive responses and off-target effects of genetic manipulations and chemical interventions, can impact the mechanisms of cell death

Neyra et al., 2023

While this should logically increase the muscle-building effects, IGF-1 LR3 would also then bypass the internal feedback regulatory pathways, theoretically increasing the risk of negative side effects of excessive growth hormone pathway activity