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The follicle is embedded within an extracellular matrix (ECM) a complex scaffolding of proteins including collagen, laminin, and fibronectin that provides structural support, facilitates cellular communication, and delivers biochemical signals essential to follicular function

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Also searched were the Agency for Healthcare Research and Quality evidence reports, Clinical Evidence, the Cochrane database, Essential Evidence, the Institute for Clinical Systems Improvement, the National Guideline Clearinghouse database, and the U.S

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