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However, recent studies have revealed that several bioactive molecules (cytokines, proteins, peptides, metabolites, and microRNAs) are also involved in the regulation of bone metabolism and bone homeostasis, and they regulate bone remodeling by signaling between the bone and other tissues in the form of paracrine and endocrine secretions (Kelch et al., 2017)

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Clinical trials show average weight loss of 15-22% over 68 weeks on semaglutide alone, with some patients reaching 25%+ loss