Kidney Stones Having kidney stones or a condition that blocks the flow or urine, such as a tumor or an enlarged prostate, can trap urine in your bladder and contribute to a UTI or another infection
Serious adverse effects requiring clinical vigilance include: Lactic acidosis : A rare but potentially fatal complication of metformin, particularly in patients with renal impairment (eGFR 10%), symptomatic hyperglycemia, diagnostic uncertainty, or recurrent hypoglycemia
Similarly, the protective effects of metformin on subchondral bone are indirect, occuring through cartilage integrity preservation and oxidative stress reduction 54
GLP-1 receptor agonists confer no increased rates of IBD exacerbation among patients with IBD
Schedule a Weight Loss Consultation If you are interested in GLP-1 weight loss treatment in Bethesda , Roxborough Clinic can help determine whether semaglutide or tirzepatide is right for you