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Common symptoms include fatigue, weight gain, dry skin, constipation, and increased sensitivity to cold

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Mild, transient diarrhoea is a recognised and generally manageable side effect of retatrutide

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However, statistical correction for on-trial HbA1c level, blood pressure change, and bodyweight decrease did not significantly alter the observed decreases in albuminuria induced by GLP-1 receptor agonists in several CVOTs [66], suggesting that the renal protective effects of GLP-1 receptor agonists are not entirely due to improvements in risk factors