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Advantage : Semaglutide Summary and Verdict# Amycretin shows potentially superior weight loss (up to 24.3% in Phase 1b/2a) compared to semaglutide (14.9% in STEP 1), driven by its dual GLP-1/amylin mechanism in a single molecule

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In addition, two homologs, GGTLC1 (previously GGTL6, GGTLA4) and GGTLC2, which may only encode the light-chain portion of GGT, as well as at least three other homologs, exhibit activity: GGT5 (formerly GGL, GGTLA1/GGT-rel), GGT6 (formerly rat GGT6 homologous) and GGT7 (formerly GGTL3, GGT4) (28)

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