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PYY binds to specific Y2 receptors in the arcuate nucleus of the hypothalamus, actively inhibiting orexigenic (hunger-promoting) NPY/AgRP neurons

This deficiency is common, affecting approximately 6% of people under the age of 60 and 20% of people over the age of 60

Stop taking Mounjaro immediately and seek urgent medical assessment Signs of dehydration from persistent vomiting or diarrhoea: reduced urination, extreme thirst, confusion, or dizziness Symptoms of hypoglycaemia that do not resolve with usual measures: confusion, loss of consciousness, seizures Contact your GP or diabetes specialist nurse promptly if you notice: Persistent or worsening gastrointestinal symptoms that interfere with nutrition, hydration, or quality of life Right upper abdominal pain, fever, or yellowing of the skin/eyes (jaundice), which could indicate gallbladder problems New or unexplained symptoms such as severe headaches or palpitations If you have diabetic retinopathy and notice vision changes, seek prompt review Symptoms suggestive of thyroid abnormalities: a lump in the neck, hoarseness, difficulty swallowing, or persistent cough Recurrent skin reactions, unexplained rashes, or injection site problems Difficulty managing blood glucose levels or frequent hypoglycaemic episodes For urgent but non-emergency concerns , contact NHS 111 for advice, especially outside of GP hours

2023;136:e233e234

10.1080/09513590.2018.1488958 Gynecol Endocrinol