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This dimerization allows Nrf2 to bind to antioxidant response elements (AREs), activating the transcription of a variety of genes encoding cytoprotective, antioxidant, and phase II detoxification proteins [39,40,41,42]

The bedtime timing matters because the goal is to amplify a pulse that would otherwise occur naturally during deep sleep, not to introduce a daytime pulse that conflicts with normal pituitary rhythms

However, by the time you turn sixty, it is shown that the number decreases to around eighty micrograms per liter

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