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There are two types of prescription only vitamin B12 medicines that are listed in the British National Formulary (BNF) by NICE (National Institute for Health and Care Excellence) to be used for treating vitamin B12 deficiencies hydroxocobalamin and cyanocobalamin

Vedolizumab is licensed for both UC and CD for induction and maintenance therapy and is available as IV and SC formulations[86]

In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)