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It affects the skin on the feet and, left untreated, can spread to toenails and even to your hands

doi: 10.1038/ni.3577 65 HochreinSMWuHEcksteinMArrigoniLHermanJSSchumacherFet al

Unlike topical application, mesotherapy bypasses the stratum corneum entirely delivering active ingredients at therapeutic concentrations precisely at the level of melanocytes in the papillary dermis

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