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In a 12-month study of healthy older adults, MK-677 increased fat-free mass by about 1.6 kg compared with placebo , although it did not clearly improve strength or functional performance

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In the present study, we characterized high glucose-induced toxicity in renal tubular epithelial cells both in vivo and in vitro by means of several complementary assays, including cell viability, cell death assays and the assessment of the changes in the ultrastructure of HK-2 cells

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