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The clinical consequences extend beyond glucose metabolism

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These side effects are related to delayed gastric emptying, which is a sustained effect of semaglutide rather than a peak-dependent one

Clinicians should conduct a thorough baseline assessment before initiating semaglutide in MS patients, including: Evaluation of current MS disease activity and disability status Assessment of gastrointestinal function and neurogenic bowel symptoms Review of concurrent medications, particularly MS treatments Screening for diabetic retinopathy if diabetes is present (semaglutide may increase risk of diabetic retinopathy complications) [9] [23] Renal function assessment Thyroid examination and history of thyroid disorders Patients should be counseled about the importance of maintaining adequate hydration and reporting any worsening of pre-existing MS symptoms