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Our laboratory has recently synthesized a metabolically stable AngIV analog that acts by way of the hepatocyte growth factor (HGF)/c-Met receptor system (133136) to overcome the motor dysfunctions that follow 6-OHDA-induced lesions of the substantia nigra pars compacta in the rat (unpublished results)

BPC-157 at 0.0045 mg/lb, 0.0000045 mg/lb, or even 0.0000000045 mg/lb considerably inhibited this syndrome, particularly the hyperthermia and wet dog shake components strongly associated with 5-HT2A overactivation

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