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Wei T, Wang Q, Chen T, Zhou Z, Li S, Li Z

It has been demonstrated that NRF2 over-activation may be therapeutically beneficial for ameliorating RA owing to its anti-inflammatory and anti-oxidative activity associated with limiting cytokine production, cartilage-matrix degradation, and bone resorption 63

Together, this functional data indicates that inhibition of oxidative phosphorylation, cell cycle alterations, and mitigation of radiation-induced G2/M arrest may contribute to metformin-mediated radiosensitisation in CRC

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Ubiquitination and degradation of p61 by the E3 ubiquitin ligase TRIM21 leads to failure of p61-mediated Nrf2 activation, which reduces the antioxidant capacity of tumor cells and makes them more prone to ferroptosis