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The breakdown of oral glutathione in the gut is driven partly by the enzyme gamma-glutamyltransferase, which is why a conventional tablet raises blood glutathione only slightly (Buonocore et al., Oxidative Medicine and Cellular Longevity 2016, PMID 26649136)

Using a 29 to 31 gauge needle, allowing the solution to reach room temperature, and injecting slowly all minimize discomfort

10.1016/j.foodchem.2017.03.042 Food Chem