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Awad MM, Oxnard GR, Jackman DM, Savukoski DO, Hall D, Shivdasani P, et al

Figure 5 4.4 Direct TAM cancer cell ferroptosis interactions: a mechanistic narrative Tumor-associated macrophages (TAMs) orchestrate ferroptotic sensitivity in cancer cells through a set of tightly interlinked metabolic and immunological interactions ( Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states

Epub 2023/03/01

Reads were aligned to the mouse GRCm38 genome using STAR v.2.5.2b