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doi: 10.1056/NEJMoa2032183 85 ClinicalTrials.gov NCT03574597

Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In mice and rats, standard two-year carcinogenicity studies with insulin glargine were performed at doses up to 0.455 mg/kg, which was for the rat approximately 65 times the recommended human subcutaneous starting dosage of 0.2 units/kg/day (0.007 mg/kg/day) on a mg/kg basis

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Mechanism of Action: Direct vs Upstream Intervention IGF-1 LR3 functions as a long-acting IGF-1 receptor agonist