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Dual Glucagon-Like Peptide 1 and Glucose-Dependent Insulinotropic Polypeptide Agonist Glucose-dependent insulinotropic polypeptide (GIP) is an incretin secreted by the K cells in the jejunum in response to nutrient ingestion, with glucose-dependent insulinotropic and context-dependent glucagonotropic actions [15, 63]

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Abbreviations 4-MMP: 4-Methylmorpholine ASBT: Apical sodium bile acid transporter DCC: Dicyclohexylcarbodiimide DOCA: Deoxycholic acid DMEM: Dulbeccos modified Eagles medium DMF: N,N -Dimethylformamide EMCS: 6-Mleimidohexanoic NHS GBSW: Generalized born with simple switching GI: Gastrointestinal GLP-1A: Glucagon-like peptide 1 agonist HBSS: Hanks balanced salt solution IPGTT: Intraperitoneal glucose tolerance test KRBB: KrebsRinger bicarbonate buffer MD: Molecular dynamics MDCK: MadinDarby canine kidney cells PBS: Phosphate-buffered saline PK: Pharmacokinetic References Heller SR, Peyrot M, Oates SK, Taylor AD