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References: [1] Eli Lilly becomes first drugmaker to hit trillion-dollar m-cap on weight-loss demand boom, November 2025: [2] Orozco-Ruiz et al

3.4 Model development The GLP-1RA-related GISEs in patients with T2DM were predicted based on four factors (i.e., age, gender, number of combined oral medications, and history of gastrointestinal disorders), which were plotted as a nomogram ( Figure 2 )

Why to avoid : FDA warnings against use for skin lightening due to serious adverse effects including liver dysfunction and anaphylactic shock No proven efficacy for skin lightening High risk of complications Not approved for cosmetic use What the Science Really Says Clinical Trial Results Current evidence is mixed but shows some promise for specific applications