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Weve seen plenty of exciting animal models in chronic pain research that havent made it through to clinical practice

Subjects without events of interest were censored at the end of their in-trial period

In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis

This sustained activation of GLP-1 pathways leads to measurable changes in eating behavior and metabolic rate within the first two to four weeks of treatment