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The chemical constituents of the ENDS e-liquid, by additive or synergistic interactions, induce adverse responses and toxicity upon heating

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A key assumption of permutation tests is exchangeability and therefore, we permuted the exposure conditional on the subject (e.g., exposure was permuted on the HBEC values from a single donor, not across donors) and kept the numbers of permuted observations under each condition the same as the observed results

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