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doi: 10.1177/0271678X16688919

To understand molecular mechanisms of the dual and triple agonism conferred by tirzepatide and peptide 20, we determined five cryo-electron microscopy (cryo-EM) structures, including GIPR and GLP-1R bound with tirzepatide and GIPR, GLP-1R and GCGR bound with peptide 20, all in complex with G s proteins at global resolutions of 3 simm simm simm simm.ac.cn (M.-W.W) Supplemental files (seven PDBs and their maps) updated

In a 2-year study dapagliflozin did not significantly affect bone mineral density at the lumbar spine, femoral neck, or total hip (228)

10.1016/j.freeradbiomed.2020.07.017 3

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