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Interestingly, Lpl expression was slightly increased, possibly reflecting a compensatory mechanismdespite reduced thermogenic drive

Moreover, leptin can cross the BBB and bind to receptors in the arcuate nucleus of the hypothalamus, regulating neurotransmitters such as neuropeptide Y (NPY), cocaine-amphetamine regulated transcript (CART), serotonin (5-HT), and neuropeptide U (NPU), thereby in-directly influencing the bone-brain neural network (61)

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Many patients find it challenging to navigate these programs without support