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( A ) Quantification of TMPRSS2 protein levels in the intestinal epithelial cells isolated from lean WT fasted and refed mice

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Oral administration of 10 mg/kg of EGCG from a presymptomatic stage delays the onset of the disease and prolongs useful life, in addition to increasing the number of motor neurons, decreasing the activation of the microglia, reducing the concentration of NF-kB, caspase-3 and iNOS in a transgenic mouse model of ALS (Xu et al., 2006) (Table 1)