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In healthy humans, the plasma betaine concentration ranges from 20 to 70 mol/L (Lever et al., 1994

2012)was found to be elevated in animals supplemented with high doses of paraxanthine and caffeine, irrespective of age

EaglesSmith CA, Silbergeld EK, Basu N, Bustamante P, Daz-Barriga F, Hopkins WA, Kidd KA, Nyland JF (2018) Modulators of mercury risk to wildlife and humans in the context of rapid global change

PEM, which is characterized by an exacerbation of symptoms following physical or cognitive exertion, is also observed in FM and may be related to increased pain severity post-exertion (Barhorst et al., 2013)

It can protect the red blood cells in the blood from oxidative damage, maintenance of hemoglobin in the cysteine in a reduced state