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Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome

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violet), no significant difference was observed

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[43] Analysis results of 4-chloro-3-hydroxybutyronitrile are as follows: [44] 1 H-NMR(CDCl ): 2.79(2H, m), 3.65(2H, d), 3.86(1H, s), and 4.2O(1H, m) ppm [45] [46] Example 2: Preparation of ethyl 4-chloro-3-hydroxybutyrate (3) [47] 35.37 g of 4-chloro-3-hydroxybutyronitrile was placed in 73.22 mL of 95 % ethanol to which 32.18 mL of cone, sulfuric acid was then gradually added