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This is an important task in light of the ever-growing prevalence of this disorder while no effective pharmacological treatment has been found so far

an effect that has led to FDA approval of several GLP-1 therapies specifically for obesity

Lancet 398 (10295), 143155 (2021)

If we can modulate its action without side effects, it is a therapeutic avenue for type 2 diabetes. Researchers used specially bred male mice with pancreatic beta cells lacking the receptor to testosterone (the androgen receptor)