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This is due to a change in carbohydrate metabolism, specifically an increased production of the pro-inflammatory acetate and a decreased production of butyrate, which strengthens the intestinal barrier and has anti-inflammatory effects (162)

The rising popularity of HEETS signifies a shift towards cleaner smoking options

Any subsequent withdrawal pangs should not be seen as a sign of deprivation, but as the death throes of the "little monster." Carr encourages ex-smokers to greet these pangs with a positive thought: "Isn't it marvelous

however, they offer an opportunity for expanding our understanding of smoking behavior and lung cancer risk and may lead to new approaches to address ethnic/racial disparities in smoking and the risk of lung cancer