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Published trial averages: Semaglutide: ~1015% of body weight Tirzepatide: ~1522% of body weight A typical arc: minimal change during early titration, a steadier phase over the following months, then a maintenance phase

SGLT2i use was associated with a significantly increased risk of DKA (RR 2.08 [95% CI 1.05, 4.12] p =0.0309)

Zepbound, or tirzepatide in general, while operating under the same mechanism as other GLP-1 drugs, may exhibit subtle differences in its onset of effects due to its formulation