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I've had many people email me wondering how I feel about this "40 cigarettes" comparison, which is 240 times more than I had calculated from Dr Pope's research

There is normally 10% to 20% individual variation in the amount of anesthesia patients require, so the 38% difference between smokers and nonsmokers for inducing anesthesia is substantial, Dutton said

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Reviews on Environmental Health 2019;34(2):105-124