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At clinical concentrations, pretomanid does not inhibit major CYP isoenzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19 or CYP2D6, and does not induce CYP2C9 or CYP3A4, limiting the potential for DDI trough CYPs

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Within a few years, it was noted that patients taking bupropion were reporting a decrease in their tobacco use, and by 1997, Wellbutrin received FDA approval as a safe and effective smoking cessation aid (Zyban)