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Possible mechanisms of induction of apoptosis by statins are due to their role in inhibiting HMG-CoA reductase and mevalonate synthesis

Without glutathiones facilitation, these enzymes would be unable to catalyze essential antioxidant processes

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Additionally, hyperglycemia may impair mitochondrial function, thereby affecting the expression of oxidative phosphorylation enzymes and reducing substrate utilization, thus altering the glucose metabolic patterns in TC [206]

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