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In an Mtb infection model, continuous exposure to cigarette smoke locally impaired the accumulation of antigen-presenting cells (APC) and their production of TNF-, IL-12, and RANTES (CCL5)

The nicotine experience is 2 out of 5 compared to similar snuff and dip products

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After the release of the 1964 Surgeon Generals report focusing on the health effects of cigarette smoking, major cigar manufacturers aimed to increase the appeal of little cigars and cigarillos to cigarette smokers